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用链服佐菌素（streptozotocin，STZ）分别诱导SD和自发性高血压大鼠（Spontaneouslyhypertensiverats，SHR），建立伴有（SHRDM）和不伴有（SDDM）高血压的糖尿病动物模型，以SHR大鼠为高血压对照，SD大鼠为正常的对照组，每组再分为1、48、16、24周5个时相点，每个时相点5只
SD and spontaneously hypertensive rats (SHR) were induced respectively with streptozotocin (STZ) to establish diabetic animal models with and without SHDM (SDDM) Rats as hypertension control, SD rats as a normal control group, each group is divided into 1,48,16,24 weeks 5 time points, each time point 5