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咦岛素的发现已有60多年历史,它的发现开创了糖尿病治疗的新时代,给糖尿病患者带来了福音。在糖尿病的治疗中,过去一直采用皮下这射给药方法。由于需要终身用药,频繁的注射给病人带来痛苦与不便,因此,有人致力于非注射剂型的研究,从60年代至今,研究的非注射剂型有:口服剂型,栓剂型,眼结膜囊给药及呼吸道给药的相应剂型等。我室在研制胰岛素非注射剂型时,开始研制口服剂型,后又研制鼻腔给药剂型——滴鼻剂,笔者结合自己进行的研究工作和文献复习,现概述如下。
It has been more than 60 years since its discovery, and its discovery has created a new era in the treatment of diabetes and brought gospel to people with diabetes. In the treatment of diabetes, the subcutaneous injection method has been used in the past. Due to the need for life-long medication, frequent injections are painful and inconvenient for the patient. Therefore, there has been a focus on non-injectable dosage forms. From the 1960s to the present, non-injectable dosage forms for study include oral dosage forms, suppository dosage forms, And respiratory tract corresponding dosage form and so on. My room in the development of non-insulin dosage forms, began to develop oral dosage forms, and then developed nasal dosage form - nasal drops, the author’s own research and literature review, are summarized below.