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目的研究平衡感受器嵴顶对旋转椅试验的生物力学响应,为前庭系统功能状态的评估提供定量分析的平台。方法基于健康志愿者右侧颞骨完整的组织切片数据进行三维几何重建。运用拉格朗日法数值模拟头前倾30毅、频率0.8Hz、幅度依40毅的正弦摆动旋转椅试验中受试者前庭系统膜迷路的生物力学响应。结果右耳水平半规管嵴顶峰值位移为54.2μm,后规管嵴顶峰值位移为15.9μm;右耳前半规管嵴顶峰值位移为43.7μm,但是左右耳响应相同,对眼球运动的作用相互抵消;向右旋转,右耳水平半规管壶腹嵴嵴顶法向位移从管侧偏向椭圆囊侧,左耳水平半规管壶腹嵴嵴顶法向位移从椭圆囊侧偏向管侧,向左旋转时则相反。结论数值模拟得到的嵴顶的生物力学响应符合Flourens定律和Ewald定律。
Aim To study the biomechanical response of the spinous-bones to the spinous-chair test and to provide a quantitative analysis platform for assessing the functional status of the vestibular system. Methods Three-dimensional geometric reconstruction was performed based on the complete histological sections of the right temporal bone of healthy volunteers. The biomechanical response of the vestibular membranous labyrinth of the vestibular system was simulated by the Lagrange method numerically in a sinusoidal swivel chair with a head tilt of 30 °, a frequency of 0.8 Hz and an amplitude of 40 Hz. Results The peak displacement of crest of the right semicircular canal in right ear was 54.2μm and the peak displacement of posterior crest of crest was 15.9μm. The peak displacement of crest of right semicircular canal in right ear was 43.7μm, but the left and right ear responses were the same and the effects on eye movement offset each other. Rotate to the right, the right ear horizontal semicircular canal ampulla crest normal displacement from the tube side devoted to the side of the elliptical capsule, left ear horizontal semicircular canal ampulla crest normal displacement from the side of the elliptical capsule biased toward the tube side, the opposite rotation . Conclusions The biomechanical response of crest obtained by numerical simulation accords with Flourens law and Ewald’s law.