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目的 :研究中成药戊己胶囊对动物胃肠道系统的影响。方法 :采用幽门结扎 ,胃排空 ,胃肠推进运动 ,醋酸扭体反应以及番泻叶致泻模型观察戊己胶囊对胃肠系统的影响。结果 :戊己胶囊能显著减少大鼠胃液分泌和胃酸排出量 ,抑制小鼠胃肠推进运动 ,明显减慢小鼠的胃排空 ,对醋酸诱发的小鼠扭体反应以及番泻叶引起的小鼠泻下作用均有明显的影响。结论 :戊己胶囊具有抑制胃肠运动、镇痛、止泻作用。
Objective: To study the effect of Chinese patent medicine, Wu-ji capsule on animal gastrointestinal system. Methods: The effect of Geng capsule on gastrointestinal system was observed by pylorus ligation, gastric emptying, gastrointestinal propulsion, acetic acid writhing reaction and senna diarrhea model. Results: EHG capsule can significantly reduce gastric secretion and gastric acid secretion in rats, inhibit gastrointestinal motility in mice, significantly reduce gastric emptying in mice, acetic acid-induced writhing reaction in mice and senna induced Diarrhea in mice have a significant effect. Conclusion: EHG capsule can inhibit gastrointestinal motility, analgesic and antidiarrheal effects.