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目的研究芸香甙（Ｒｕ）的胃粘膜保护作用。方法利用３种大鼠溃疡模型观察Ｒｕ、Ｒｕ＋西咪替丁对胃粘膜损伤指数的影响；利用幽门结扎法收集胃液，观察Ｒｕ对胃液分泌量、胃液酸度和胃蛋白酶活性的影响。结果Ｒｕ（５，１０，２０ｍｇ·ｋｇ－１×２次·ｄ－１×５ｄ，ｉｇ）可剂量依赖性地抑制冷冻－束缚应激和酸性乙醇引起的胃粘膜损伤，Ｒｕ可提高Ｈ２受体阻断药西咪替丁对胃粘膜的保护作用；而Ｒｕ对消炎痛诱发的胃粘膜损伤无保护作用。Ｒｕ对大鼠胃液分泌量、胃液酸度和胃蛋白酶活性也无明显影响。结论Ｒｕ具有胃粘膜保护作用；Ｒｕ与西咪替丁之间的协同作用可为胃溃疡的药物治疗提供实验数据。
Objective To study the gastric mucosal protective effect of rutin (Ru). Methods The effects of Ru and Ru + cimetidine on gastric mucosal injury index were observed by using three kinds of rat ulcer model. The gastric juice was collected by pylorus ligation to observe the effect of Ru on gastric juice secretion, gastric acidity and pepsin activity. Results Ru (5, 10, 20 mg · kg-1 × 2 times · d-1 × 5d, ig) inhibited gastric mucosal injury induced by freeze-restraint stress and acidic ethanol dose- Blocking drug cimetidine on gastric mucosal protective effect; and Ru on indomethacin-induced gastric mucosal injury without protective effect. Ru had no effect on gastric juice secretion, gastric acidity and pepsin activity. Conclusion Ru has a protective effect on gastric mucosa. The synergistic effect between Ru and cimetidine can provide experimental data for the treatment of gastric ulcer.