目的:观察硫普罗宁(THIOLA)改善甲氨蝶呤致儿童肝损害的疗效。方法:采用硫普罗宁注射剂防治甲氨蝶呤所引起的肝损害103例,并在同样条件下用美能(β-甘草酸复方制剂StrongerNeo-MinophagenC)防治肝损害42例作为对照,对比肝功能各项实验室检测指标。结果:治疗组,对照组对化疗中造成的肝损害都具有明显的疗效,33%未表现明显肝损害,67%表现明显肝功能异常,继续使用保肝药后肝功能恢复正常。治疗组与对照组效果无显著差异(P>0.05)。结论:硫普罗宁在急性淋巴细胞白血病患儿化疗时同步应用,可有效地保护肝细胞,明显改善肝功能,其效果与美能相同。 Objective: To observe the efficacy of thiophene (THIOLA) in improving liver damage induced by methotrexate in children. Methods: 103 cases of liver damage caused by methotrexate were treated with tiopronin injection. In the same condition, 42 cases of liver damage were treated with the combination of StrongerNeo-Minophagen C (β-glycyrrhizin) Laboratory test indicators. Results: The treatment group and the control group all had obvious curative effect on liver damage caused by chemotherapy. 33% did not show obvious liver damage and 67% showed obvious abnormal liver function. The liver function returned to normal after continuing to use liver protection medicine. There was no significant difference between the treatment group and the control group (P> 0.05). CONCLUSIONS: Tiopronin is used simultaneously in patients with acute lymphoblastic leukemia during chemotherapy, which can effectively protect liver cells and improve liver function obviously.