目的:建立人血浆中阿斯匹林和水杨酸气相色谱-质谱联用测定法,并研究了肠溶阿斯匹林片在健康人体内的药代动力学。方法:色谱柱HP-525m×0.2mmID石英弹性毛细管柱。内标苯甲酸,血样酸化后经乙醚-二氯甲烷(4:1)提取,BSTFA衍生化进样,采用选择离子方式检测、定量。结果:阿匹斯林、 OBJECTIVE: To establish a method for the determination of aspirin and salicylic acid in human plasma by gas chromatography-mass spectrometry and to study the pharmacokinetics of enteric-coated aspirin tablets in healthy volunteers. Methods: The column HP-525m × 0.2mmID quartz capillary column. Internal standard benzoic acid, acidified blood samples were extracted with ether-methylene chloride (4: 1), and derivatized with BSTFA. The selected ions were detected and quantified. Results: Apisline,