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内耳病毒感染可伴发耳聋。虽曾建立内耳病毒感染的动物模型,但病毒感染内耳的途径还不清楚。作者对18只雄豚鼠经右圆窗接种0.002ml Hanta病毒液入耳蜗,感染后4、6、8、10、12、16天各处死3只;2只雄豚鼠同样方法接种无病毒的培养液,作为对照;另18只雄豚鼠经腹腔内接种此病毒液1ml,其中6只于接种前3天给予环磷酰胺(CY,250mg/kg),6只接种前1天和接种后5天给予环孢霉素A
Inner ear virus infection may be associated with deafness. Although animal models of infection of the inner ear virus have been established, the pathways that the virus infects the inner ear are unclear. Eighteen male guinea pigs were inoculated intraperitoneally with 0.002 ml Hanta virus into the cochlea through the right circular window and killed 3 on days 4, 6, 8, 10, 12 and 16. Two male guinea pigs were vaccinated with virus-free medium in the same way The other 18 male guinea pigs were intraperitoneally inoculated with 1 ml of this virus solution, of which 6 were given cyclophosphamide (CY, 250 mg / kg) 3 days prior to vaccination, 6 days before inoculation and 5 days after inoculation A