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目的探讨亚临床甲状腺功能减退症患儿血脂水平变化的意义。方法选取30例亚临床甲状腺功能减退症(亚临床甲减)患儿(亚临床甲减组)及30例体检健康儿童(健康对照组)。应用罗氏全自动生化分析仪P800和罗氏化学发光免疫分析仪E170分别检测其总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、脂蛋白a[LP(a)]和促甲状腺激素(TSH)、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)水平。结果亚临床甲减组儿童血清TC[(4.14±0.88)mmol.L-1]、TG[(1.88±0.42)mmol.L-1]及LP(a)[(209.9±122.92)mg.L-1]水平显著高于健康对照组(Pa<0.01)。亚临床甲减组FT3、FT4与健康对照组比较差异无统计学意义;TSH水平与健康对照组比较差异有统计学意义。结论亚临床甲减可引起儿童血脂代谢异常。
Objective To investigate the significance of blood lipid levels in children with subclinical hypothyroidism. Methods Thirty children with subclinical hypothyroidism (subclinical hypothyroidism) (subclinical hypothyroidism) and 30 healthy children (healthy control group) were selected. The total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), lipoprotein (HDL) were measured by Roche automatic biochemical analyzer P800 and Roche chemiluminescence immunoassay analyzer E170 a [LP (a)], thyrotropin (TSH), free triiodothyronine (FT3) and free thyroxine (FT4). Results Serum TC [(4.14 ± 0.88) mmol.L-1], TG [(1.88 ± 0.42) mmol.L-1] and LP (a) [(209.9 ± 122.92) 1] was significantly higher than the healthy control group (Pa <0.01). Clinical subclinical hypothyroidism FT3, FT4 compared with the healthy control group no significant difference; TSH levels compared with the healthy control group, the difference was statistically significant. Conclusion Subclinical hypothyroidism can cause abnormal blood lipid metabolism in children.