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不久前Houff和Plotkin等先后著文描述由于角膜移植造成狂犬病毒在人与人之间传播,提示对狂犬病脑病病例有必要进行常规筛选。作者于1944—45年起便以上述筛选作为病毒学诊断的第一步。例如将活检或尸检的脑标本进行常规乳鼠脑内接种试验,1964年至今共接种600多份次;考虑在某些病例病毒可能被抗体抑制,以后同时将常规接种标本作免疫荧光染色,1969年后共做了340份次,16例狂犬病获确诊(1964年后4例)。但所有疑似病例却无1例获证实。这些结果表明对此病进行常规筛选仍然是值得的。应强调的是,只是在采用新鲜或冷冻的未
Not long ago, Houff and Plotkin, who successively published articles describing the spread of rabies virus from person to person as a result of corneal transplantation, suggested routine screening of rabies encephalopathy cases is necessary. The authors used the above screening as a virological diagnosis as a first step in 1944-45. For example, biopsy or necropsy brain samples were routinely inoculated intrabraintly in neonatal mice and were inoculated more than 600 times since 1964. Considering that in some cases the virus may be inhibited by antibodies, routinely inoculated samples will be immunofluorescently stained later. 1969 After the year a total of 340 times, 16 rabies was diagnosed (after 1964 4 cases). However, none of the suspected cases was confirmed. These results suggest that routine screening of the disease is still worth it. It should be stressed that only fresh or frozen ones are not used