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口腔癌前病变(OPL)有不同程度的癌变危险性。最近研究表明,丧失特异的染色体区域即杂合性缺失(LOH),是OPL随后进展的早期预兆。对OPL的LOH分析将提高临床医生的确诊及处理高危险性癌前病变的能力。
Oral precancerous lesions (OPL) have varying degrees of cancer risk. Recent studies have shown that loss of a specific chromosomal region, loss of heterozygosity (LOH), is an early omen for the subsequent progression of OPL. LOH analysis of OPL will improve clinicians’ ability to diagnose and treat high-risk precancerous lesions.