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目的探讨颅内动脉硬化患者不同部位血管的动脉硬化程度及其相关性。方法将193例有动脉硬化基础疾病的患者进行颈动脉、下肢动脉血管超声及头颅核磁共振动脉成像(MRA)检查,根据头颅MRA结果分为颅内动脉硬化组和非颅内动脉硬化组。采用Pearson相关、Binary Logistic分析周围动脉与颅内动脉硬化关系;绘制接受者操作特性(ROC)曲线。结果随着颈动脉硬化(CAS)及下肢动脉硬化(LLAS)程度的增高颅内动脉硬化有逐渐增加的趋势,CAS组U值为1.87(P>0.05),LLAS组U值为2.80(P<0.05);CAS及LLAS与颅内动脉硬化的相关系数分别为0.12(P=0.05)、0.21(P<0.05);Logistic分析显示CAS及LLAS相对于颅内动脉硬化的OR值分别为0.86(P>0.05)和0.67(P<0.05);CAS、LLAS的ROC曲线下面积分别57.80%(P>0.05)、62.20%(P<0.05),LLAS界值点为2级。结论 LLAS与颅内动脉硬化密切相关,为颅内动脉硬化的独立危险因素,LLAS≥2级有一定的预测颅内动脉硬化的作用。
Objective To investigate the degree of atherosclerosis and its correlation in different regions of patients with intracranial arteriosclerosis. Methods Ninety-three patients with underlying arteriosclerosis underwent carotid and lower extremity arterial ultrasound and MRA. According to the results of craniocerebral MRA, they were divided into intracranial arteriosclerosis group and non-intracranial arteriosclerosis group. Pearson correlation and Binary Logistic analysis were used to analyze the relationship between peripheral arteries and intracranial arteriosclerosis. The receiver operating characteristic (ROC) curve was drawn. Results With the increasing of carotid atherosclerosis (CAS) and lower extremity atherosclerosis (LLAS), intracranial arteriosclerosis tended to increase. The U value was 1.87 in CAS group and 2.80 in LLAS group (P < 0.05). The correlation coefficients of CAS and LLAS with intracranial arteriosclerosis were 0.12 (P = 0.05) and 0.21 (P <0.05) respectively. Logistic analysis showed that the OR of CAS and LLAS relative to intracranial arteriosclerosis were 0.86 > 0.05) and 0.67 (P <0.05). The areas under ROC curve of CAS and LLAS were 57.80% (P> 0.05) and 62.20% (P <0.05), respectively. Conclusion LLAS is closely related to intracranial atherosclerosis and is an independent risk factor for intracranial atherosclerosis. LLAS≥2 has some predictive effects on intracranial arteriosclerosis.