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对未习服热暴露附加运动负荷（游泳）动物的运动能力以及某些生化指标泌乳素（ＰＢＬ）、皮质醇（Ｃｏｒｔ）、血栓素（ＴｘＢ２）、前列环素（ＰＧＦＩａ）、唾液酸（ＴＳＡ）、过氧化脂质（ＬＰＯ）、超氧化物歧化酶（ＳＯＤ）、肺泡动脉氧压差（Ａ－ａＤＯ２）等进行了动态监测；并用冷冻蚀刻、电子密度示踪及电镜酶组织化学等技术对热负荷动物的心、肺、肾及小肠等细胞膜结构与功能进行了系统的研究，发现：（１）大鼠热暴露后游泳能力明显降低，与未受高温影响的单纯游泳组比较有极显著性差异（Ｐ＜０．０１）；（２）热负荷使体内Ｃｏｒｔ，ＰＲＬ等水平急剧上升，肺通气障碍，出现代谢性酸中毒，导致对机体有保护作用的物质如ＨＧＦＩ，ＳＯＤ等水平降低或代偿，对机体有损伤作用的物质如ＴｘＢ２，ＬＰＯ等大量释放；（３）细胞能量代谢障碍，细胞膜上酶活性减弱，其转运水、电解质及代谢产物的能力亦明显降低，对大分子物质硝酸镧的通透性显著增加，细胞内外电位差及渗透压不能维持；（４）多数器官细胞膜内微粒数量明显减少，且分布异常；（５）全身系统多器官、多种细胞成份广泛受损，运动能力迅速降低；（６）受热停止４－２４ｈ上述各项指标无明显恢复迹象，迟发性损伤明显。
The results showed that there was no significant difference in the exercise capacity and the biochemical indexes of PBL, Cort, TxB2, PGFIa, TSA (LPO), superoxide dismutase (SOD) and alveolar arterial oxygen pressure difference (A-aDO2) were detected dynamically. The cells were stained with freeze-thaw, electron density tracing and electron microscopy histochemical techniques The structure and function of the membrane of heart, lung, kidney and small intestine in heat-stressed animals were systematically studied and found that: (1) The swimming ability of rats after heat exposure was significantly lower than that of the simple swimming group without high temperature (P <0.01). (2) The heat load increased the levels of Cort and PRL in the body sharply. The pulmonary ventilation disorder and metabolic acidosis caused the body protective substances such as HGFI and SOD Reduce or compensate, the body has a damaging effect of substances such as TxB2, LPO and other large (3) cell energy metabolism disorders, cell membrane enzymatic activity weakened its ability to transport water, electrolytes and metabolites also significantly reduced the permeability of the macromolecular substance lanthanum nitrate significantly increased potential difference between cells and outside and osmotic pressure Can not be maintained; (4) the number of the majority of organs within the cell membrane decreased significantly, and the distribution is abnormal; (5) multiple organs of the body system, a wide range of cellular components were impaired, rapidly reduced exercise capacity; (6) No significant signs of recovery indicators, delayed damage significantly.