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使用硫酸镁治疗10例新生儿持续肺动脉高压，饱和量200mg／kg，静脉推注。维持量20—150mg／kg／h静脉滴注，平均治疗时间71．0±12．8小时，未使用其他扩管药和高频通气治疗。动脉血氧分压由治疗前的5．50±1．20kpa升至治疗24小时后的9．25±2．10kpa（P＜0．01）；氧气指数及肺泡－动脉氧气阶度在治疗24小时后显著降低，分别由44．76±10．74降至27．30±9．31（P＜0．01），由628．25±15mmHg降至498．20±48．10mmHg（P＜0．05）；机械通气平均气道压由治疗前17．52±0．40mH2O降至治疗72小时后的12．72±0．32cmH2O（P＜0．01）。9例患儿治愈，治愈率90％。故认为硫酸镁在新生儿持续肺动脉高压治疗中值得提倡。
Ten cases of neonatal pulmonary hypertension were treated with magnesium sulfate, with a saturation of 200 mg / kg and intravenous injection. To maintain the volume of 20-150mg / kg / h intravenous infusion, the average treatment time 71.0 ± 12.8 hours, did not use other expansion tube drugs and high-frequency ventilation treatment. Arterial partial pressure of oxygen rose from 5.50 ± 1.20kpa before treatment to 9.25 ± 2.10kpa after 24 hours of treatment (P <0.01); oxygen index and alveolar-arterial oxygen level in treatment 24 Hour and significantly decreased from 44.76 ± 10.74 to 27.30 ± 9.31 (P <0.01), from 628.25 ± 15 mmHg to 498.20 ± 48.10 mmHg (P <0 .05). Mean airway pressure of mechanical ventilation decreased from 17.52 ± 0.40mH2O before treatment to 12.72 ± 0.32cmH2O after 72h (P <0.01). Nine patients were cured, the cure rate was 90%. Therefore, magnesium sulfate in the treatment of neonatal pulmonary hypertension should be advocated.