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目的:观察比较持续皮下输注赖脯胰岛素与常规注射预混赖脯胰岛素对老年非初诊2型糖尿病患者的疗效与安全性。方法:将58例老年2型糖尿病患者随机分为观察组(29例)与对照组(29例),观察组用赖脯胰岛素经胰岛素泵持续皮下输注(CSI-I),对照组用精蛋白锌重组赖脯胰岛素25注射液,2次/d,常规皮下注射。两组患者均给予糖尿病教育、饮食控制及适量运动,共治疗2周。比较治疗前后两组患者的血糖、胰岛素用量、血糖达标时间以及低血糖发生率。结果:治疗后两组患者空腹血糖、餐后血糖均较治疗前下降(P<0.05),观察组血糖达标时间、胰岛素用量均明显低于对照组(P<0.05)。两组低血糖发生率无明显差异。结论:持续皮下输注赖脯胰岛素具有较好的疗效与安全性,是控制老年非初诊2型糖尿病患者较佳的方法。
Objective: To observe the efficacy and safety of continuous subcutaneous infusion of insulin lispro and routine injection of premixed insulin lispro on elderly non-newly diagnosed type 2 diabetic patients. Methods: 58 elderly patients with type 2 diabetes mellitus were randomly divided into observation group (n = 29) and control group (n = 29). The observation group was treated with insulin lispro sustained insulin infusion (CSI-I) Recombinant insulin lispro 25 injection of zinc, 2 times / d, conventional subcutaneous injection. Two groups of patients were given diabetes education, diet control and moderate exercise for a total of 2 weeks. Before and after treatment, the two groups of patients with blood glucose, insulin dosage, blood glucose compliance time and the incidence of hypoglycemia. Results: After treatment, the fasting blood glucose and postprandial blood glucose in both groups decreased compared with before treatment (P <0.05). The observed time and insulin dosage in the observation group were significantly lower than those in the control group (P <0.05). No significant difference in the incidence of hypoglycemia between the two groups. CONCLUSIONS: Sustained subcutaneous infusion of insulin lispro has good efficacy and safety and is the preferred method for controlling elderly non-newly diagnosed type 2 diabetic patients.