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目的探讨主要组织相容性抗原-Ⅰ(MHC-Ⅰ)表达在多发性肌炎诊断中的作用。方法收集进行肌肉活检的54例患者临床资料,活检肌肉组织进行常规病理检查及 MHC-Ⅰ免疫组织化学染色,以评价 MHC-Ⅰ表达在多发性肌炎诊断中的价值。结果在16例多发性肌炎患者中,炎细胞浸润阳性率63%,MHC-Ⅰ表达阳性率94%;在19例进行性肌营养不良患者中炎细胞浸润阳性率5%;MHC-Ⅰ表达阳性率11%;在19例其他肌病及非肌病患者均未发现 MHC-Ⅰ表达和炎性细胞浸润。结论 MHC-Ⅰ表达作为多发性肌炎的组织学诊断指标,灵敏度、特异度及阴性似然比均较为理想,是一个合适的指标。
Objective To investigate the role of major histocompatibility antigen-I (MHC-Ⅰ) in the diagnosis of polymyositis. Methods The clinical data of 54 patients who underwent muscle biopsy were collected. The biopsy muscle tissue was collected for histopathological examination and MHC-Ⅰ immunohistochemical staining to evaluate the value of MHC-Ⅰ expression in the diagnosis of polymyositis. Results In 16 patients with polymyositis, the positive rate of inflammatory cell infiltration was 63% and the positive rate of MHC-Ⅰ expression was 94%. The positive rate of inflammatory cell infiltration was 5% in 19 patients with progressive muscular dystrophy. The expression of MHC-Ⅰ The positive rate was 11%. No MHC-Ⅰ expression and inflammatory cell infiltration were found in 19 other myopathies and non-myopathies. Conclusion MHC-Ⅰ expression as a histological diagnosis of polymyositis indicators, sensitivity, specificity and negative likelihood ratio are ideal, is a suitable indicator.