Objective: To explore the correlation between common syndrome essential factors and the symptoms and signs of unstable angina (UA).Methods: Eight hundred and fifteen patients with UA confirmed by coronary angiography were identified from several centers.Common syndrome essential factors were selected on the basis of expert experience.The correlations between common syndrome essential factors and symptoms and signs of UA were analyzed using binary logistic regression analysis.Results: The common syndrome essential factors in unstable angina were blood stasis,qi stagnation,phlegm turbidity,heat stagnancy,qi deficiency,yin deficiency,and yang deficiency.Symptoms such as chest pain,hypochondriac distention,ecchymosis,dark orbits,dark and purplish tongue,and tongue with ecchymosis and petechiae were significant diagnostic features of “blood stasis”.Aversion to cold and cool limbs,weakness in the waist and knees,and clear abundant urine were significant diagnostic features of “yang deficiency”.These results were in accordance with the understanding of traditional clinical Chinese medical practice.Conclusion: This clinical study analyzed the correlations between common syndrome essential factors and the symptoms and signs of unstable angina.The results provide the basis for establishing diagnostic criteria for syndrome essential factors.