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用放射免疫分析(RIA)法检测68例糖尿病、44例高血压病患者及30名正常人的24小时尿白蛋白(ALb)、免疫球蛋白G(IgG)和β_2微球蛋白(β_2mG)排泄量。结果表明,糖尿病肾病和高血压肾病的尿ALb、IgG、β_2mG均增高;糖尿病和高血压病并发肾脏病变时常伴有肾小管病变,病程与其肾损害的发生、发展及严重程度有关;糖尿病较高血压病患者发生紧损害早、进展快,后者肾小管病变早于肾小球。提示用RIA法检测糖尿病和高血压病患者的尿ALb、IgG、β_2mG,有助于早期判定其并发肾病时的病变部位及病损程度。
Radioimmunoassay (RIA) was used to detect the excretion of 24 hours urinary albumin (ALb), IgG and β_2 microglobulin in 68 patients with diabetes mellitus, 44 patients with essential hypertension and 30 healthy controls. the amount. The results showed that the urinary ALb, IgG and β_2mG of diabetic nephropathy and hypertensive nephropathy were all increased. The diabetic nephropathy and hypertension complicated with nephropathy were often associated with tubulointerstitial disease. The course of the disease was related to the occurrence, development and severity of renal damage. Diabetes mellitus Tight blood pressure damage occurred in patients with early, rapid progress, the latter early renal tubulointerstitial lesions. It is suggested that the urine ALb, IgG and β_2mG in patients with diabetes mellitus and hypertension can be detected by RIA method, which is helpful for the early determination of the lesion and lesion degree when it is complicated by nephropathy.