本实验对克汀病模型大鼠软骨的生长和代谢进行了观察。作为软骨发育标志的碱性磷酸酶在低碘组显著低于加碘组(P<0.02),提示克汀病大鼠软骨发育迟缓。实验表明,碱性磷酸酶的降低与甲低状态密切相关,是软骨发育障碍的根源。本实验未能提示出骨的钙化有何变化,血清钙磷测定结果未发现两组间有差异。 In this experiment, the growth and metabolism of cartilage in rats with cretinism were observed. Alkaline phosphatase, a marker of cartilage development, was significantly lower in the iodine-deficient group than in the iodized group (P <0.02), suggesting cartilage retardation in the cretinism rats. Experiments show that the reduction of alkaline phosphatase and hypothyroidism is closely related to the root causes of cartilage development disorders. The experiment failed to suggest any change in the bone calcification, serum calcium and phosphorus test results did not find any difference between the two groups.