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一、返流性食管炎返流性食管炎是由于食管下部括约肌(LES)压力降低,胃内容物返流入食管,损伤食道粘膜所致。目前主要使用抗酸剂、H_2受体阻断剂中和胃酸、抑制酸排泄和分泌,但最近市售的作用于局部胃粘膜壁细胞的H~+/K~+-ATP 酶阻断剂奥美拉唑(omeprazol)的划时代药效颇引人注目。随着生活方式的欧美化,本病正在增多,必须进行强有力的抑酸治疗,故该药可成为特效药。许多研究报道,奥美拉唑20mg/日,二周症状消失,四周治愈率达75%。
First, regurgitated esophagitis Reflux esophagitis is due to lower esophageal sphincter (LES) pressure decreases, the stomach contents back into the esophagus, damage caused by esophageal mucosa. At present, antacids and H 2 receptor blockers are mainly used to neutralize gastric acid and inhibit acid excretion and secretion. However, the recently marketed H ~ + / K ~ + -ATPase inhibitor, which acts on local gastric mucosal parietal cells The epoch-making efficacy of omeprazol is striking. With the lifestyle of Europe and the United States, the disease is increasing, must be a strong acid suppression treatment, so the drug can become a cure. Many studies have reported that omeprazole 20mg / day, two weeks disappeared symptoms, four weeks cure rate of 75%.