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本研究致力于探讨定量质子磁共振波谱(MRS)对鉴别良性与恶性脑膜瘤的价值。研究利用1.5T磁共振仪,对23例脑膜瘤(良性组(WHO I级)19例,恶性组(WHOⅡ～Ⅲ级)4例)进行单体素MRS检查(PRESS序列,TR/TE=2000ms/68,136,272ms),通过指数衰减模型估计组织水和胆碱(Choline,Cho)的T2弛豫时间,并以组织水为内参照计算Cho的绝对浓度,然后按MRS体素内坏死或囊变组织的比例对Cho浓度进行校正。研究发现,良、恶性脑膜瘤的组织水T2弛豫时间分别是(105±41)ms和(151±42)ms,差异有显著性(P=0.033)。良、恶性脑膜瘤的Cho T2弛豫时间分别是(242±73)ms和(316±102)ms,无显著差异(P=0.105)。良、恶性脑膜瘤的Cho浓度在校正前分别是(2.86±0.86)mmol/kg wet weight和(3.53±0.60)mmol/kg wet weight,在校正后分别是(2.98±0.93)mmol/kg wet weight和(4.58±1.22)mmol/kg wet weight,校正后差异具有显著性(P=0.019)。研究表明,用定量质子磁共振波谱测定组织水T2弛豫时间和Cho绝对浓度,对鉴别良性和恶性脑膜瘤具有重要的参考价值。
This study focused on the quantitative proton magnetic resonance spectroscopy (MRS) in the differential diagnosis of benign and malignant meningiomas. In this study, we performed single-element MRS (PRESS sequence, TR / TE = 2000 ms) in 23 cases of meningioma (19 in WHO grade I and 4 in WHO II ~ III) / 68,136,272ms), the T2 relaxation time of tissue water and choline (Cho) was estimated by exponential decay model, and the absolute concentration of Cho was calculated by using tissue water as an internal reference, then the MRS voxel necrosis or cystic degeneration The Cho ratio was corrected for Cho concentration. The study found that the tissue T2 relaxation time of benign and malignant meningiomas was (105 ± 41) ms and (151 ± 42) ms, respectively, with significant difference (P = 0.033). The Cho T2 relaxation time of benign and malignant meningiomas was (242 ± 73) ms and (316 ± 102) ms, respectively, with no significant difference (P = 0.105). The Cho concentrations in benign and malignant meningiomas were (2.86 ± 0.86) mmol / kg wet weight and (3.53 ± 0.60) mmol / kg wet weight before correction, respectively And (4.58 ± 1.22) mmol / kg wet weight, respectively. The corrected difference was significant (P = 0.019). Studies have shown that the use of quantitative proton magnetic resonance spectroscopy T2 relaxation time and water tissue tissue absolute concentration of Cho for differential diagnosis of benign and malignant meningiomas has important reference value.