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目的 通过研究模拟失重情况下下肢顺应性的变化及双下肢静脉加压套带的影响 ,探讨模拟失重后立位耐力下降的机理和静脉加压套带防护作用的机理。 方法 6名健康男性志愿者进行了两次 7d- 6°头低位卧床试验。第一次试验时 3名受试者卧床中使用双下肢加压充气套带 ,压力40 mm Hg,每天 8:0 0～ 2 0 :0 0使用 12 h;另 3名受试者不使用任何对抗措施。第二次试验时两组受试者互换。在卧床前和卧床第 7d进行的立位试验中测量了受试者右侧小腿截面积的变化 ;在卧床前、第6 d和起床后第 2 d应用静脉阻断法测量了在阻断压力分别为 2 0、30、5 0、70和 80 mm Hg时受试者右侧小腿截面积的变化。 结果 立位试验和静脉阻断法中较高阻断压力时 ,卧床后对照组下肢顺应性明显增加 (立位 10 min时 ,P<0 .0 5 ) ,而套带组有下降趋势。 结论 下肢顺应性的增加可能是模拟失重后立位耐力下降的原因之一 ;双下肢加压套带阻止头低位卧床后立位耐力的下降 ,部分是通过阻止下肢顺应性的增加而实现的
OBJECTIVE: To investigate the mechanism of the drop of standing endurance and the protective mechanism of intravenous compression after simulated weightlessness by studying the changes of lower limb compliance and the effects of venous pressure cuffs on both lower extremities. Methods Six healthy male volunteers underwent 7d-6 ° head-down ambulation. The first trial of three subjects in the bed with double lower extremity compression inflatable cuff, pressure 40 mm Hg, 8: 00 ~ 20: 0 0 daily use of 12 h; the other three subjects do not use any Countermeasure. The second test subjects were swapped. The changes of cross-sectional area of the right leg of the subject were measured in the orthostatic test on the 7th day before bedtime and in the bedridden time. The venous occlusion pressure The cross-sectional area of the right leg of the subjects was 20, 30, 50, 70 and 80 mm Hg, respectively. Results In the standing test and the higher occlusion pressure in the vein occlusion method, the compliance of the lower extremities of the control group after bedridden was significantly increased (P <0.05 at 10 min after standing position), and decreased in the control group. Conclusions The increased compliance of the lower extremities may be one of the reasons for the decrease of standing endurance after simulated weightlessness. The reduction of the standing endurance of the lower extremities after bed rest with the lower extremity compression bandage is partly achieved by preventing the lower limbs from increasing compliance