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目的 探讨老年 2型糖尿病患者血清胰岛素样生长因子 1(IGF 1)与骨质疏松发生发展的关系。方法 测定 4 0例老年 2型糖尿病合并骨质疏松患者和 5 8例老年 2型糖尿病无骨质疏松患者的骨密度、IGF 1、空腹血糖、空腹胰岛素等值 ,进行对照、比较、研究。结果 老年 2型糖尿病合并骨质疏松患者血清IGF 1水平比无骨质疏松的老年 2型糖尿病患者明显降低 (P <0 .0 5 )。结论 IGF 1是一个骨生成的强刺激因子 ,在老年 2型糖尿患者骨质疏松发生及发展中 ,起着重要的作用
Objective To investigate the relationship between serum insulin - like growth factor 1 (IGF - 1) and the development of osteoporosis in elderly type 2 diabetic patients. Methods BMD, IGF 1, fasting plasma glucose and fasting insulin in 40 elderly patients with type 2 diabetes mellitus and 58 elderly patients with type 2 diabetes without osteoporosis were measured and compared. Results The serum level of IGF1 in elderly type 2 diabetic patients with osteoporosis was significantly lower than that of type 2 diabetic patients without osteoporosis (P <0.05). Conclusion IGF 1 is a strong stimulator of osteogenesis and plays an important role in the development and progression of osteoporosis in elderly type 2 diabetic patients