Objective: To explore the ameliorative effect and mechanism of Panax notoginseng (PNG) and Ticlid in treating early diabetic nephropathy (DN). Method: Fifty-eight patients were divided randomly into two groups, 28 patients of the Ticlid group treated with Ticlid 250 mg orally, once a day and 30 patients of the PNG group treated with PNG 8 ml in 250 ml of normal saline intravenous drip once a day. The therapeutic effect and relative indexes of the two groups were observed and compared. Results: After treatment, in both groups, the thromboxane B 2 markedly reduced and was more prominent in the Ticlid group (P<0.05), while the 6ketoprostaglandin F 1α increased obviously, so as to cause a significant lowering of T/K ratio, P<0.01. Levels of urinary albumin, β 2 microglobulin and blood α 1 microglobulin of both groups were lowered significantly, P<0.01. A significant positive linear correlation was found in the Ticlid group between urinary albumin and T/K ratio (r=0.41, P<0.01), as well as in blood α 1 microglobulin with T/K ratio (r=0.34,P< 0.05), while it was not found in the PNG group. Conclusion: Ticlid and PNG were beneficial to resume the balance of T/K ratio and improve microcirculation, reduce whole blood viscosity and decrease urinary albumin so as to retard the progress of DN. Objective: To explore the ameliorative effect and mechanism of Panax notoginseng (PNG) and Ticlid in treating early diabetic nephropathy (DN). Method: Fifty-eight patients were divided randomly into two groups, 28 patients of the Ticlid group treated with Ticlid 250 mg orally, once a day and 30 patients of the PNG group treated with PNG 8 ml in 250 ml of normal saline intravenous drip once a day. Therapeutic effect and relative indexes of the two groups were observed and compared. Results: After treatment, in Both groups, the thromboxane B 2 markedly reduced and was more prominent in the Ticlid group (P <0.05), while the 6ketoprostaglandin F 1α increased obviously, so as to cause a significant lower T / K ratio, P <0.01. Levels of P <0.01. A significant positive linear correlation was found in the Ticlid group between urinary albumin and T / K ratio (r = 0.41, P <0.01). The urinary albumin, β 2 microglobulin and blood α 1 microglobulin of both groups were significantly decreased, , As well as in blood α 1 microglobulin with T / K ratio (r = 0.34, P <0.05), while it was not found in the PNG group. Conclusion: Ticlid and PNG were beneficial to resume the balance of T / K ratio and improve microcirculation, reduce whole blood viscosity and decrease urinary albumin so as to retard the progress of DN.