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2例患者静脉滴注加替沙星引发高血糖。第1例为81岁男性,因慢性阻塞性肺疾病急性加重,给予加替沙星0.4g+5%葡萄糖注射液250ml静脉滴注,1次/d。3d后患者出现烦躁、多尿、口渴、疲劳,血糖由用药前6.01mmol/L升至28.84mmol/L。立即停用加替沙星,给予12U胰岛素静脉滴注,2d后血糖恢复到5.2mmol/L。第2例为61岁男性梗阻性胆管炎、胆汁淤积性肝硬化患者,给予加替沙星0.4g+5%葡萄糖注射液250ml静脉滴注,1次/d,谷胱甘肽1.2g+葡萄糖氯化钠注射液250ml静脉滴注,1次/d,消炎利胆片6片,3次/d。治疗后第4天,血糖由用药前的5.60mmol/L升为13.81mmol/L。遂停用加替沙星,改为克林霉素静脉滴注。3d后血糖降至5.84mmol/L。
Two patients with intravenous infusion of gatifloxacin induced hyperglycemia. The first case of an 81-year-old man, given an acute exacerbation of chronic obstructive pulmonary disease, was given gatifloxacin 0.4g + 5% glucose injection 250ml intravenously 1 time / d. After 3d patients with irritability, polyuria, thirst, fatigue, blood sugar before treatment by 6.01mmol / L rose to 28.84mmol / L. Gatifloxacin was stopped immediately, given intravenous infusion of 12U insulin, blood glucose returned to 5.2mmol / L after 2d. The second case of obstructive cholangitis in 61-year-old man with cholestatic cirrhosis was given gatifloxacin 0.4g + 5% glucose 250ml intravenous infusion, 1 / d, glutathione 1.2g + glucose chloride Natrium Injection 250ml intravenous infusion, 1 / d, anti-inflammatory gallbladder tablets 6, 3 times / d. On the fourth day after treatment, the blood glucose rose from 5.60 mmol / L before treatment to 13.81 mmol / L. Then disable gatifloxacin, clindamycin intravenously. After 3d blood sugar dropped to 5.84mmol / L.