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早期静脉注射尿激酶(UK)治疗急性心肌梗塞(AMI),能缩小梗塞范围,降低死亡率。目前应用大剂量UK静脉注射价格昂贵,且易发生出血并发症。为探索UK的安全有效剂量,我院将1988年3月至1991年4月间31例符合溶栓指征的AMI患者分为大剂量UK(100万u)组与中等剂量UK组(50万u)。两组对比溶栓成功率分别为62.5％与66.7％,无明显差别(P>0.05)。现报道如下。病例选择与方法病例选择溶栓指征:(1)年龄≤70岁;(2)持续胸痛>0.5h,静滴硝酸甘油无效;(3)发病时间6h以内或在24h内心电图ST段仍呈单项曲线,没有病理性Q波;(4)心电图符合AMI的证据;(5)无溶栓禁忌症。符合上述溶栓指征的31例AMI患者按入院顺序分为两组:I组16例,男14例,女2例。平均年龄50.9±8.9岁。梗塞部位:前间壁3例,前壁5例,下壁5例,广泛前壁3例。室性早搏7例,Ⅲ
Early intravenous urokinase (UK) in the treatment of acute myocardial infarction (AMI), can reduce infarct size, reduce mortality. The current application of high-dose UK intravenous injection is expensive, and prone to bleeding complications. To explore the safe and effective dose of UK, we divided 31 AMI patients who were eligible for thrombolytic indications between March 1988 and April 1991 into high-dose UK (1 million u) group and middle-dose UK group (500 thousand u). The successful rates of contrast-induced thrombolysis in two groups were 62.5% and 66.7%, respectively, with no significant difference (P> 0.05). Report as follows now. Case selection and methods of patient selection Thrombolytic indications: (1) ≤ 70 years of age; (2) continuous chest pain> 0.5h, intravenous nitroglycerin ineffective; (3) within 6h onset or within 24h ECG ST segment was still Single curve, no pathological Q wave; (4) evidence of ECG consistent with AMI; (5) no thrombolytic contraindications. According to the above thrombolytic indications, 31 patients with AMI were divided into two groups according to hospital admission order: 16 cases in group I, 14 males and 2 females. The average age of 50.9 ± 8.9 years. Infarction site: anterior wall in 3 cases, anterior wall in 5 cases, inferior wall in 5 cases, extensive anterior wall in 3 cases. Premature ventricular contractions in 7 cases, Ⅲ