论文部分内容阅读
目的:利用斑点追踪成像技术探讨压力负荷型心衰小鼠的心衰发展进程中左心室整体及局部心功能的变化情况,为预测心衰的发展提供新思路。方法:用小鼠重度胸主动脉缩窄模型模拟压力负荷型心衰发生发展情况,术后1-12周每周监测手术组和假手术组小鼠常规心脏超声和斑点追踪成像参数的变化情况。结果:手术组小鼠术后1周即出现射血分数、纵向应变、径向应变、环向应变等左心室整体心功能参数的降低以及心尖部、心中部、心底部局部应变的下降,随着时间的进展,术后第7周出现整体纵向应变和心尖部纵向应变的进一步下降,第8周出现整体和局部各段心功能的全面下降。结论:在心衰的发展过程中,纵向应变先于常规心脏超声参数和径向应变、环向应变发生失代偿性损伤,心尖部纵向应变先于心中部和心底部出现损伤。
OBJECTIVE: To study the changes of left ventricular global and regional cardiac function during development of heart failure in pressure-overload heart-failure mice by speckle tracking imaging and to provide new ideas for predicting the development of heart failure. Methods: The development of pressure overload heart failure was simulated with the model of severe thoracic aorta in mice. The change of routine echocardiography and speckle tracking imaging parameters in the operation group and the sham operation group were monitored weekly from 1 to 12 weeks after operation . Results: The left ventricular global cardiac function parameters such as ejection fraction, longitudinal strain, radial strain and circumferential strain decreased and the local strain decreased at 1 week after operation in the operation group With the progress of time, the overall longitudinal strain and the longitudinal strain of the apical portion were further decreased at the 7th week after operation. At the 8th week, there was an overall decline in global and regional cardiac function. Conclusion: In the process of heart failure, longitudinal strain precedes conventional cardiac ultrasound parameters and radial strain, and circumferential strain is decompensated. Longitudinal strain of the apical portion precedes injury in the middle part of the heart and in the bottom of the heart.