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目的探讨椎管内良性转移性平滑肌瘤(BML)的临床病理特征,以提高对该病的认识。方法对1例BUL手术患者的肿瘤组织行HE及免疫组化染色检查。结果镜下显示为梭形细胞肿瘤,细胞异型性小,未见明显核分裂象,未见坏死。免疫组化:瘤细胞SMA、SM-MHC、desmin、ER(50%)、PR(85%)和vimentin(+),S-100和CD117(-),Ki-67阳性指数为2%和血管内皮细胞CD34(+)。结合临床、形态及免疫表型,病变符合良性转移性平滑肌瘤。结论 BML是一种少见的肿瘤,多发生于有子宫平滑肌瘤手术史的女性患者。当椎管发生占位时要考虑到此病的可能,掌握其临床病理特征对于诊断该病具有重要意义。
Objective To investigate the clinicopathological features of benign metastatic leiomyomata (BML) in spinal canal to improve the understanding of the disease. Methods Tumor tissues from 1 BUL patients were examined by HE and immunohistochemistry. Results Microscopy showed spindle cell tumors, cell atypia, there was no obvious mitosis, no necrosis. Immunohistochemistry: The positive cells of SMA, SM-MHC, desmin, ER (50%), PR (85%) and vimentin (+), S-100 and CD117 Endothelial cells CD34 (+). Combined with clinical, morphological and immunophenotype, the lesion is consistent with benign metastatic leiomyomata. Conclusion BML is a rare tumor that occurs in female patients with a history of uterine leiomyoma surgery. When the occurrence of spinal canal to take into account the possibility of this disease, to grasp its clinical and pathological features for the diagnosis of the disease is of great significance.