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目的探讨头孢哌酮/舒巴坦钠预防老年急性呼吸衰竭感染的有效性与安全性。方法 63例老年急性呼吸衰竭患者随机分为试验组32例和对照组31例。对照组静脉滴注盐酸环丙沙星注射液0.1 g,每日2次,试验组静脉滴注头孢哌酮/舒巴坦钠3.0 g,加入0.9%NaCl 250 m L中,每日2次;2组均治疗7 d。比较2组患者的有效率和不良反应发生率等。结果试验组治疗有效率和无效率分别为90.62%(29/32例)和9.38%(3/32例),对照组治疗有效率和无效率分别为54.84%(17/31例)和45.16%(14/31例),差异有统计学意义(P<0.05)。不良反应主要表现为恶心、头晕、食欲不振和稀便,试验组不良反应发生率为9.38%(3/32例),对照组不良反应发生率为19.35%(6/31例),差异有统计学意义(P<0.05)。结论应用头孢哌酮/舒巴坦钠预防老年急性呼吸衰竭感染有效率高,且不良反应发生率低。
Objective To investigate the efficacy and safety of cefoperazone / sulbactam in preventing senile acute respiratory failure. Methods Sixty-three elderly patients with acute respiratory failure were randomly divided into experimental group (32 cases) and control group (31 cases). The control group was given 0.1 g ciprofloxacin hydrochloride injection twice daily. The test group was given cefoperazone / sulbactam sodium 3.0 g 0.9% NaCl 250 mL twice daily. Both groups were treated for 7 days. Compare the two groups of patients with effective rate and adverse reaction rate. Results The effective rate and ineffective rate in the experimental group were 90.62% (29/32 cases) and 9.38% (3/32 cases) respectively. The effective rate and inefficiency rate in the control group were 54.84% (17/31 cases) and 45.16% (14/31 cases), the difference was statistically significant (P <0.05). Adverse reactions mainly manifested as nausea, dizziness, loss of appetite and loose stools, the incidence of adverse reactions in the experimental group was 9.38% (3/32 cases), the incidence of adverse reactions in the control group was 19.35% (6/31 cases), the difference was statistically Significance (P <0.05). Conclusion The application of cefoperazone / sulbactam sodium in the prevention of senile acute respiratory failure infection is effective and the incidence of adverse reactions is low.