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目的探讨甲氨蝶呤与米非司酮联合治疗异位妊娠的临床疗效。方法将2010年1月-2012年3月诊治的158例异位妊娠患者随机分成两组:实验组79例,采用甲氨蝶呤+米非司酮治疗;对照组79例,单纯采用米非司酮治疗。观察和比较两组的临床疗效、平均住院时间、包块吸收情况、血β-HCG值变化以及不良反应发生情况。结果实验组的总有效率显著性高于对照组(P<0.05);实验组的平均住院时间明显短于对照组(P<0.05);实验组治疗后的包块大小和血β-HCG值显著小于对照组(P<0.05);两组的不良反应发生率相比差异无统计学意义(P>0.05)。结论临床应用甲氨蝶呤与米非司酮联合治疗异位妊娠的临床效果显著。
Objective To investigate the clinical efficacy of methotrexate combined with mifepristone in the treatment of ectopic pregnancy. Methods 158 cases of ectopic pregnancy diagnosed and treated from January 2010 to March 2012 were randomly divided into two groups: experimental group (n = 79) treated with methotrexate and mifepristone; control group (n = 79) Cholesterol treatment. The clinical efficacy, average length of stay, mass absorption, change of blood β-HCG and the incidence of adverse reactions were observed and compared between the two groups. Results The total effective rate of the experimental group was significantly higher than that of the control group (P <0.05). The average length of stay in the experimental group was significantly shorter than that of the control group (P <0.05) (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Clinical application of methotrexate and mifepristone combined treatment of ectopic pregnancy has a significant clinical effect.