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从大鼠后足掌部向踝关节皮下注射蛋清0.1毫升,半小时后踝关节卽呈腫胀且消退很慢。如于注射蛋清前半小时腹腔注射秦艽甲90毫克/千克,則踝关节部腫胀程度较轻,且消退亦快。但在去除两侧腎上腺的大鼠及用戊巴此妥纳麻醉的正常大鼠,则预先注射秦艽甲并不能抑制蛋清性“关节炎”的产生,亦不促进其消退。可见秦艽甲对蛋清性“关节炎”的作用必须在动物两侧腎上腺保持完整时才能发生。但秦艽甲并非直接作用于腎上腺,而是通过神经系统的。秦艽甲对因注射甲醛而产生的“关节炎”的作用也是如此。预先注射氯喹、秦艽中性酒精浸剂、水杨酸鈉或考地松,虽不抑制蛋清性“关节炎”的产生,但都能加速关节部腫胀的消退。对因注射甲醛而产生的“关节炎”的治疗作用,秦艽鹼甲甲与氯喹、考地松及秦艽中性酒精浸剂相似,但较水杨酸钠略强。
0.1 ml of egg white was subcutaneously injected into the ankle from the dorsal palmar of the rat, and the ankle was swollen and subsided very slowly in half an hour. Such as half an hour before injection of egg white Qinhuang A 90 mg / kg, the ankle swelling less, and faded quickly. However, in rats with both adrenal glands removed and normal rats anesthetized with pentobarbital, premedication did not inhibit egg white “arthritis” nor did it promote its resolution. It can be seen that Gentiana macrophylla on egg white “arthritis” role must be kept intact on both sides of the animal to occur. But Qin A does not act directly on the adrenal gland, but through the nervous system. The same applies to the effect of “arthritis” caused by injection of formaldehyde. Pre-injection of chloroquine, Gentiana neutral alcohol infusion, sodium salicylate or testosterone, although not inhibit egg white “arthritis”, but can accelerate the swelling of the joints subsided. For the treatment of “arthritis” caused by the injection of formaldehyde, the camptothecin, camptothecin, is similar to chloroquine, toadranthus and gentiana, but slightly stronger than sodium salicylate.