类风湿性关节类(RA)是与自身免疫反应密切相关的疾病,包括类风湿因子(RF)在内的多种血清自身抗体巳成为诊断本病和估计预后的重要指标。1979年Young等发现RA病人血清中存在着一种自身抗体,能与动物食管上皮的角质层抗原特异性地结合。并称之为抗角蛋白抗体(Antikeratin antibody, AKA)。随后许多学者对AKA的生物学特性及其与RA的关系进行了一系列的研究,认为AKA是RA病人血清中的一种特异性抗体,在RA的诊断和 Rheumatoid arthritis (RA) is a disease closely related to the autoimmune reaction, and various serum autoantibodies including rheumatoid factor (RF) have become important indicators for diagnosis of the disease and prognosis. In 1979, Young et al. Found that there is an autoantibody in the serum of RA patients that specifically binds to the stratum corneum antigen of animal esophageal epithelium. And called anti-keratin antibody (Antikeratin antibody, AKA). Subsequently, many scholars conducted a series of studies on the biological characteristics of AKA and its relationship with RA. AKA is a specific antibody in the serum of patients with RA. In the diagnosis and