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许多西方国家报道，近10余年来脑膜炎球菌性疾病持续性增加。该病总病死率＜10％，但休克型及紫疫暴发型可达25％－50％，暴发型中许多存活者需截肢或截指（趾）。曾报道用重组的人杀菌素／渗透性增加蛋白的氨基酸末端片段（rBPI21），治疗26例1－18岁重症脑膜炎球菌血症儿童。
Many western countries have reported sustained increases in meningococcal disease over the past decade or so. The overall case fatality rate was <10%, but up to 25% -50% of shock and purple-storm outbreaks were reported in many survivors of the fulminant type requiring amputation or phalanges. A total of 26 children aged 1-18 years with severe meningococcal disease have been reported using the recombinant human spinosad / endopeptidase-enhanced amino acid fragment (rBPI21).