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采用5种与分化表型有关的抗体：CK－HMW、CK－LMW、SC、CgA、Syn对60例肺大细胞癌进行免疫组织化学观察。结果显示，5种抗体表达率分别为CK－HMW16．7％，CK－LMW56．7％，SC35．0％，CgA35．0％，Syn43．4％。在免疫组化分化表型上，60例肺大细胞癌可分为向腺分化者27例（45％）、鳞分化者5例（8．3％）、NE分化者22例（36．7％）、腺鳞分化者3例（5％）、腺鳞神经内分泌分化者2例（3．3％）、无分化表型者1例（1．7％）。结果表明，CK－LMW及CK－HMW可分别作为腺及鳞分化的标记。Syn对鉴别肺大细胞癌的NE分化更有意义。多种抗体联合检测才能更全面地反映肺大细胞癌的分化表型。不同分化表型肺大细胞癌的临床病理意义有待于进一步研究和探讨。
Using 5 kinds of antibodies related to differentiation phenotype: CK-HMW, CK-LMW, SC, CgA, Syn, 60 cases of large cell lung cancer were observed by immunohistochemistry. The results showed that the five antibody expression rates were 16.7% for CK-HMW, 56.7% for CK-LMW, 35.0% for SC-LMW, 35.0% for CgA, and 43.4% for Syn. In the immunohistochemical differentiation phenotype, 60 cases of large cell lung cancer can be divided into 27 cases (45%) of gonad differentiation, 5 cases of squamous differentiation (8.3%), and 22 cases of NE differentiation (36.7). %), adenosquamous differentiation of 3 cases (5%), adenosquamous neuroendocrine differentiation in 2 cases (3.3%), indifferent phenotype in 1 case (1.7%). The results showed that CK-LMW and CK-HMW can be used as markers of glandular and squamous cell differentiation, respectively. Syn is more meaningful in distinguishing NE differentiation of large cell lung cancer. Multiple antibody combinations can more fully reflect the differentiation phenotype of large cell lung cancer. The clinicopathological significance of different differentiated phenotype lung large cell carcinoma remains to be further studied and discussed.