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临床研究表明，神经根有炎症表现者，根性疼痛的临床表现就明显，这似乎提示，神经根性疼痛与局部的炎症反应密切相关。本实验选用SD雄性大鼠45只，分为三组，即对照组、逐痰通络汤治疗组和芬必得治疗组。建立神经根压迫模型，分别在造模后4天、10天、30天处死动物。取神经根周围局部组织，用生化方法测定其中前列腺素E2，5-羟色胺、组织胺水平，以探讨化学性神经根炎症的机理及逐痰通络汤对局部炎症的抑制作用。结果表明：（1）逐痰通络汤对降低受压神经根周围局部炎症介质水平具有明显作用。（2）神经根压迫局部炎症介质水平的测试，对解释化学性神经根炎症机理及探讨中药疗效是必要指标。同时对中药治疗神经根痛的作用机理作了探讨。
Clinical studies have shown that there are manifestations of nerve root inflammation, clinical manifestations of root pain is obvious, which seems to suggest that radicular pain is closely related to the local inflammatory response. In this experiment, 45 male SD rats were selected and divided into three groups: control group, Zhuyu Tongluo Decoction treatment group and Fenbid group. A nerve root compression model was established and animals were sacrificed at 4, 10, and 30 days after modeling. The local tissues around the nerve roots were taken and the levels of prostaglandin E2, serotonin, and histamine were measured by biochemical methods to investigate the mechanism of chemical nerve root inflammation and the inhibitory effect of Zhuyu Tongluo Decoction on local inflammation. The results showed that: (1) Zhuyu Tongluo Decoction has a significant effect on reducing the level of local inflammatory mediators around the compressed nerve root. (2) The test of nerve root compression on the level of local inflammatory mediators is an essential indicator for explaining the mechanism of chemical nerve root inflammation and exploring the efficacy of traditional Chinese medicine. At the same time, the mechanism of Chinese medicine treatment of radiculopathy was discussed.