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本文介绍一种治疗急性心肌梗塞的新方法。在心肌梗塞的极早期,通过冠状动脉插管滴入链激酶每分钟2,000—4,000国际单位(平均总剂量为180,000国际单位)以期溶解血栓。本组70例在梗塞发生后6小时内(平均3.6小时)进行了紧急冠状动脉造影,发现其中64例的梗塞是由冠状动脉阻塞所引起。冠状动脉内注射硝酸甘油无效。滴入链激酶后69％病例的阻塞清除满意。胸痛迅速缓解,升高的ST段回至基线,说明未梗塞区域心肌的缺血消退。未发现操作本身所引起的意外,亦无出血并发症。
This article describes a new method of treating acute myocardial infarction. In the very early stages of myocardial infarction, 2,000-4,000 IU per minute of streptokinase (mean total dose of 180,000 IU) is dropped through the coronary artery cannula in order to lyse the thrombus. The group of 70 patients within 6 hours after the onset of infarction (mean 3.6 hours) underwent emergency coronary angiography and found that 64 cases of infarction caused by coronary artery obstruction. Coronary injections of nitroglycerin are not effective. 69% of cases were blocked with streptokinase and cleared. Rapid relief of chest pain, elevated ST segment back to baseline, indicating non-ischemic myocardial infarction subsided. Did not find the operation itself caused the accident, nor bleeding complications.