论文部分内容阅读
用头孢唑肟治疗严重与难治性细菌感染61例,其中肺部感染18例。消化系统感染14例,泌尿—生殖系统感染13例,败血症8例,颅内感染4例,烧伤感染2例与颌面感染1例。病例多伴有严重的基础疾患。经治疗后,痊愈—显效率达73.3％(44/60),有效率为10％(6/60)。不良反应仅有药疹3例,念珠菌肠炎3例。其余皆轻。 经测定,57株病原菌为金葡球菌20株,MIC_(90)为32mg/L;肠道杆菌23株,MIC_(90)为1mg/L:绿脓杆菌4株,MIC为1～128mg/L。 测定血药浓度(HPLC法)5例。静滴头孢唑肟1克(1小时滴完)后的血清浓度(mg/L);半小时为7.58±4.41,1小时为20.5±2.75,6小时为4.41±2.12。
With ceftizoxime treatment of 61 cases of severe and refractory bacterial infections, including pulmonary infection in 18 cases. 14 cases of digestive system infection, urinary and reproductive system infections in 13 cases, sepsis in 8 cases, intracranial infection in 4 cases, 2 cases of burn infection and maxillofacial infection in 1 case. More cases with severe underlying disease. After treatment, healed - markedly effective rate was 73.3% (44/60), the effective rate was 10% (6/60). Adverse reactions only drug eruption in 3 cases, 3 cases of Candida enteritis. The rest are light. The results showed that 57 strains of pathogenic Staphylococcus aureus were 20 strains with MIC 90 (90) of 32 mg / L, 23 strains of enterobacteriaceae with MIC 90 of 1 mg / L and 4 strains of Pseudomonas aeruginosa with MICs ranging from 1 to 128 mg / L . Determination of plasma concentration (HPLC method) in 5 cases. Serum concentrations (mg / L) after intravenous ceftizoxime 1 g (1 hour drop-over); 7.58 ± 4.41 in one half hour, 20.5 ± 2.75 in one hour and 4.41 ± 2.12 in 6 hours.