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目的探讨血清氧化型低密度脂蛋白(Ox-LDL)及其自身抗体(Ox-LDLAb)与冠状动脉痉挛的关系及调脂治疗对其影响。方法将2009年1月至2012年3月收治的符合入选标准的冠状动脉痉挛心绞痛患者139例分为稳定型心绞痛(SAP)组80例和不稳定型心绞痛(UAP)组59例;并选取同期进行健康体检60例为健康组对三组患者治疗前、后Ox-LDL和Ox-LDLAb进行检测。结果三组治疗前Ox-LDL、Ox-LDLAb比较差异有统计学意义(P<0.05);三组治疗前与治疗后比较差异有统计学意义(P<0.05)。结论不稳定型心绞痛组Ox-LDL、Ox-LDLAb明显高于稳定型心绞痛组,说明血浆Ox-LDL、Ox-LDLAb水平与冠状动脉病变严重程度呈正相关联系;通过短期调脂治疗有效降低了氧化型低密度脂蛋白及其自身抗体,减少了冠脉痉挛的发生,减少了由冠状动脉痉挛引发的急性事件发生。
Objective To investigate the relationship between serum oxidized low density lipoprotein (Ox-LDL) and its autoantibodies (Ox-LDLAb) and coronary artery spasm and the effect of lipid-lowering therapy on it. Methods One hundred and ninety-nine patients with coronary artery spasm angina pectoris admitted from January 2009 to March 2012 were divided into stable angina (SAP) group (n = 80) and unstable angina pectoris group (UAP) group (n = 59) 60 cases of healthy physical examination for the health group on the three groups before and after treatment Ox-LDL and Ox-LDLAb were detected. Results The difference of Ox-LDL and Ox-LDLAb in three groups before treatment was statistically significant (P <0.05). There was significant difference between the three groups before and after treatment (P <0.05). Conclusions The levels of Ox-LDL and Ox-LDLAb in patients with unstable angina pectoris are significantly higher than those in patients with stable angina pectoris, indicating that the levels of Ox-LDL and Ox-LDLAb are positively correlated with the severity of coronary artery disease. Type low density lipoprotein and its autoantibodies, reducing the occurrence of coronary spasm, reducing the occurrence of acute events caused by coronary spasm.