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研究表明细胞因子参与癫痫的发病机制。本文通过综述癫痫发作早期,脑内多种细胞因子(白细胞介素、干扰素、肿瘤坏死因子-α等)表达增加,外源性及特定细胞因子转基因动物影响癫痫发作,说明细胞因子在癫痫发生过程中起作用。另外,抗炎药物治疗癫痫发作有效,提示抗炎药物可能通过调节与炎症密切相关的细胞因子水平发挥作用。然而,细胞因子参与癫痫发作的具体机制与功能尚待于进一步研究。
Research shows that cytokines are involved in the pathogenesis of epilepsy. In this paper, by reviewing the early stage of epileptic seizures, the expression of multiple cytokines (interleukin, interferon, tumor necrosis factor-alpha, etc.) in the brain increased, exogenous and cytokine transgenic animals affect seizures, indicating that cytokines in epilepsy The process works. In addition, anti-inflammatory drugs for the treatment of seizures effective, suggesting that anti-inflammatory drugs may play a role in regulating cytokines closely related to inflammation. However, the specific mechanism and function of cytokines involved in seizures remains to be further studied.