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目的:研究胃复春片对胃黏膜中、重度异型增生的治疗作用及对p 21ras、p 53蛋白表达的调节作用.探讨其逆转胃癌癌前病变的治疗价值及机制。方法:内镜下病理活检证实为中、重度异型增生患者共58例,随机分为胃复春治疗组32例,维酶素对照组26例。治疗前后比较临床疗效,镜下改变,病理改变及胃黏膜固定部位活检标本p 21ras、p 53蛋白s-P法免疫组化染色变化情况。结果:胃复春组临床症状的总有效率81.25％,内镜下改变总有效率71.88％,病理学改变总有效率65.63％,均优于维酶素对照组(分为53.85％、46.15％、34.61％)。p 21ras、P53蛋白在中、重度异型增生组织中有过度表达,胃复春能使其表达明显减弱。结论:胃复春对胃黏膜中、重度异型增生有良好的治疗作用,能促进病变胃黏膜的逆转,并对p21ras、p 53蛋白的表达有一定的调节作用,降低癌变危险性,可用于胃癌癌前病变的治疗。
Objective: To study the therapeutic effect of Weifuchun Tablet on moderate and severe dysplasia in gastric mucosa and the regulation of p21ras and p53 protein expression, and to explore its therapeutic value and mechanism of reversing gastric precancerous lesions. Methods: Endoscopic biopsy confirmed 58 cases of moderate and severe dysplasia, were randomly divided into Wei Fu Chun treatment group 32 cases, 26 cases of vitamin enzyme control group. Before and after treatment, clinical efficacy, microscopic changes, pathological changes and gastric biopsy specimens p21ras, p53 protein s-P immunohistochemical staining. Results: The total effective rate of clinical symptoms in Weifuchun group was 81.25%, the total effective rate of endometrial changes was 71.88%, the total effective rate of pathological changes was 65.63%, which was better than that of the control group of Vitexin (53.85%, 46.15% , 34.61%). p21ras, P53 protein in moderate and severe dysplasia were overexpression, Wei Fuchun can make its expression was significantly weakened. CONCLUSION: Weifuchun has a good therapeutic effect on moderate and severe dysplasia of gastric mucosa, and it can promote the reversal of gastric mucosa lesions. It also regulates the expression of p21ras and p53 protein, reduces the risk of cancer and can be used in gastric cancer The treatment of precancerous lesions.