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目的观察两种不同的药物,每组各41例治疗方案对幽门螺杆菌(Hp)阳性消化性溃疡的疗效并进行经济学评价。方法82例Hp阳性的消化性溃疡患者随机分为A、B2组,每组各41例。A组服用埃索美拉唑20mg、阿莫西林胶囊1000mg、呋喃唑酮100mg,2次/d;B组服用奥美拉唑20mg、阿莫西林胶囊1000mg、呋喃唑酮100mg,2次/d。2组疗程均为7d。疗程结束4周后,观察2组溃疡愈合率、Hp根除率、药物不良反应,并进行成本-效果分析。结果A、B组溃疡愈合率分别为95.12%、85.37%,2种方案对溃疡的疗效差异有统计学意义(P<0.05);Hp根除率分别为92.68%、85.37%,差异无统计学意义(P>0.05);A、B组每例1个疗程成本分别为209.25、82.41元。A、B组的Hp清除率及溃疡愈合率的成本-效果比分别为2.26、0.97及2.20、0.97,A组相对于B组的Hp清除率及溃疡愈合率增量成本-效果比分别为17.35、13.01。结论从成本-效果角度分析,以奥美拉唑为主的根除Hp方案优于以埃索美拉唑为主的方案。
Objective To observe the efficacy of two different drugs, 41 cases of each treatment group on Helicobacter pylori (Hp) -positive peptic ulcer and conduct economic evaluation. Methods 82 cases of Hp-positive peptic ulcer patients were randomly divided into A, B2 group, 41 cases in each group. In group A, 20 mg of esomeprazole, 1000 mg of amoxicillin and 100 mg of furazolidone were administered twice daily. Group B received omeprazole 20 mg, amoxicillin 1000 mg and furazolidone 100 mg twice daily. 2 groups of treatment are 7d. Four weeks after the end of treatment, ulcer healing rate, Hp eradication rate and adverse drug reactions were observed and cost-effectiveness analysis was performed. Results The healing rates of ulcer in groups A and B were 95.12% and 85.37%, respectively. The curative effect of the two kinds of regimens on ulcer was statistically significant (P <0.05). The rates of Hp eradication were 92.68% and 85.37% respectively, with no significant difference (P> 0.05). The costs of one course of treatment in each group of A and B were 209.25 and 82.41 yuan respectively. The cost-effect ratios of Hp clearance rate and ulcer healing rate in group A and B were 2.26, 0.97 and 2.20, 0.97, respectively. The Hp clearance rate and ulcer healing rate incremental cost-effectiveness ratio in group A and group B were 17.35 , 13.01. Conclusions From the cost-effectiveness point of view, omeprazole-based Hp regimen is superior to esomeprazole-based regimen.