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目的观测事件相关电位P300在系统性红斑狼疮(SLE)患者中的变化情况,评价P300在系统性红斑狼疮的应用价值。方法测定38例SLE患者和40例健康对照者的事件相关电位P300的潜伏期(PL)、波幅(Amp)。结果SLE患者P30,0的PL(350.3±40.8)ms,Amp为(6.5±0.15)μV,正常对照组分别为(310.6±18.5)ms、(8.3±0.18)μV,两组比较差异有统计学意义(P<0.01);临床检查有神经精神症状者8例(21.05%),P300检查异常者25例(65.78%),两种方法相比差异有统计学意义(P<0.01)。结论事件相关电位P300可作为一项较客观、有价值且为无创的评价SLE患者认知功能的指标,有助于神经精神狼疮的早期诊断。
Objective To observe the changes of P300 in patients with systemic lupus erythematosus (SLE) and evaluate the value of P300 in systemic lupus erythematosus (SLE). Methods The latency, PL, and amplitude of event-related potential P300 in 38 SLE patients and 40 healthy controls were determined. Results The P (subscript 30,0) of SLE was (350.3 ± 40.8) ms and Amp was (6.5 ± 0.15) μV in SLE patients and 310.6 ± 18.5 μ (8.3 ± 0.18) μV in normal controls, respectively (P <0.01). There were 8 cases (21.05%) with neuropsychiatric symptoms and 25 cases (65.78%) with P300 abnormalities in clinical examination. The difference between the two methods was statistically significant (P <0.01). Conclusion The event-related potential P300 can be used as an objective, valuable and non-invasive evaluation of cognitive function in patients with SLE, which is helpful for the early diagnosis of neuroleptic lupus.