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目的 :研究淋巴细胞恶性增殖性疾病 ( MPL D)患者丙型肝炎病毒感染情况及病毒基因型分布。方法 :用逆转录 PCR( RT- PCR)法对 76例 MPL D和 118例体检人群血清进行 HCV- RNA检测 ,同时用 Okamoto HCV基因分型法进行 HCV基因分型。结果 :76例 MPL D中 HCV - RNA阳性 10例 ( 13.16 % ) ,其中 2 1例非霍奇金淋巴瘤 ( NHL )中 2例阳性 ( 9.5 2 % ) ,39例多发性骨髓瘤 ( MM)中 7例阳性 ( 17.95 % ) ,16例急性淋巴细胞白血病( AL L )中 1例阳性 ( 6 .2 5 % ) ,118例体检人员中 1例阳性 ( 0 .85 % )。对 HCV感染病例 HCV分型发现 ,10例 HCV感染患者均感染 HCV- 型 ,其中 MM中 1例混合感染 HCV- 型 ,1例混合感染 HCV- 型。结论 :MPL D患者有较高的 HCV感染 ,以 MM的 HCV感染最高 ,HCV- 型是 MPL D患者 HCV感染主要基因型
Objective: To investigate the status of hepatitis C virus (HCV) infection and genotype distribution in patients with lymphoproliferative malignancies (MPL D). Methods: HCV-RNA was detected by reverse transcription PCR (RT-PCR) in 76 cases of MPL D and 118 cases of human subjects. HCV genotyping was performed by Okamoto HCV genotyping. Results: Of the 76 MPL D cases, 10 (13.16%) were HCV - RNA positive, of which 2 were non - Hodgkin ’s lymphoma (NHL), 2 were positive (9.5 2%) and 39 were multiple myeloma 7 cases were positive (17.95%), 16 cases were acute lymphoblastic leukemia (AL L) positive in one case (6.55%), and 118 cases were positive in 1 case (0 .85%). HCV genotypes of HCV-infected cases were found in 10 cases of HCV-infected patients were infected with HCV-type, of which 1 case of MM mixed infection of HCV-type, 1 case of mixed infection with HCV-type. CONCLUSIONS: Patients with MPL D have a higher HCV infection with the highest HCV infection in MM, and HCV-type is the major genotype of HCV infection in patients with MPL D