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目的观察氨氯地平联合螺内酯治疗原发性高血压疗效。方法 130例患者随机分为观察组和对照组各65例,对照组口服氨氯地平2.5mg,4次/d,晨起服用,一周后改为5mg,4次/d;观察组在此基础上加服螺内酯20mg,2次/d,疗程8周,观察两组降压效果。结果观察组总有效率93.8%,对照组总有效率81.5%,两组比较差异显著。结论氨氯地平联合螺内酯降压效果良好,不良反应少。
Objective To observe the efficacy of amlodipine combined with spironolactone in the treatment of essential hypertension. Methods 130 patients were randomly divided into observation group and control group, 65 cases, the control group oral amlodipine 2.5mg, 4 times / d, morning taking, one week later changed to 5mg, 4 times / d; observation group based on this On the service plus serotonin 20mg, 2 times / d, course of treatment for 8 weeks, the two groups observed antihypertensive effect. Results The total effective rate was 93.8% in the observation group and 81.5% in the control group, with significant difference between the two groups. Conclusions Amlodipine combined with spironolactone has a good antihypertensive effect and few adverse reactions.