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1988年4月我院收治1例毛细胞白血病患者,曾行脾切除。术后症状未缓解,毛细胞数高达80%,又试行小剂量化疗也未见缓解.病人低热、乏力、贫血、皮下瘀斑及牙龈出血、鼻衄反复出现,需2个月输血一次维持.1990年2月,我们应用国产重组干扰素人工Ⅰ型制剂“干扰灵”每日肌注20ug,连续使用180天,患者外周血毛细胞数由69%下降至3%,达到完全缓解,用药过程中未发现任何毒副反应,目前无病缓解期已达11
April 1988 admitted to our hospital 1 cases of hairy cell leukemia patients, had splenectomy. Postoperative symptoms were not alleviated, the number of hair cells up to 80%, but also tried a small dose of chemotherapy has not alleviated.Patients with fever, fatigue, anemia, subcutaneous ecchymosis and bleeding gums, epistaxis recurring need to maintain a 2-month blood transfusion. February 1990, we use domestic recombinant interferon artificial type Ⅰ preparation “Interfering Spirit” daily intramuscular injection of 20ug, continuous use of 180 days, the number of patients with peripheral blood cells decreased from 69% to 3%, to achieve complete remission, medication process In the absence of any side effects, the current disease-free remission has reached 11