8例因不同疾病而长期服用氯化奎宁的病人发生类似的视网膜病变。在出现眼部症状前,接受该治疗的时限最短为1年,其剂量最少在200克以上。每例视网膜病变均为双侧对称性。早期经常出现傍中心暗点,当病变进行时,周边视野缩小,傍中心暗点向周边及中心扩展。最早的眼底改变为黄斑部色素紊乱。晚期,黄斑区脱色素最为显著,其次为视网膜动脉及小动脉狭窄。视神经萎缩及周边视网膜广泛的脱色亦属于晚期表现。暗适应或在早期不受影响,或只有轻微改变,在晚期病例也只有中等度的改变,无1例有象视网膜色素变性那样高的阈值。按常用方法所测的视网膜电流图,在早期只有轻微改变,当视网膜病变进行时,视网膜生物电波逐渐降低,在明适应下,以相对局限的长波刺激黄斑区时,尤其明显。在病变中期视网膜电 Eight patients with long-term use of quinine chloride due to various diseases developed similar retinopathy. Before the onset of ocular symptoms, the minimum duration of the treatment is 1 year and the dose is at least 200 grams. Each case of retinopathy are bilateral symmetry. Parents often appear near the center of the dark spots, when the lesion, the surrounding vision narrowing, near the center of the dark spots to the periphery and center expansion. The earliest change to macular pigment disorders. Late, macular dextran the most significant, followed by the retinal artery and arteriolar stenosis. Optic atrophy and extensive peripheral retinal decolorization also belong to the late manifestations. Dark adaptation was either unaffected or slightly altered in the early stage, with only modest changes in the late stage, and none of them had the same high threshold as retinitis pigmentosa. According to the commonly used method of retinal current map, only a slight change in the early, when retinopathy, retinal bioelectrical waves gradually decreased, under the bright adaptation, relatively long-wave stimulation of the macular area is particularly evident. In the mid-retinal lesions