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二、喹啉类生物碱本类生物碱分为1、金鸡纳生物碱,闽台两省无产此生物碱之植物。2、喜树生物碱。3、较简单喹啉生物碱等三类。现分述如下: (一)喜树生物碱:这类生物碱具有抗癌作用,它是在五十年代末从珙(王同)科喜树(Campto-theca acuminata Decne)的木部、根及叶的提取物〔1〕〔7〕,发现具有抗癌作用。此后于1966年由Wall等人发现其树皮乙醚提取物对腺癌-755有药理活性,随后进一步证实其有效成分为喜树碱(Camptothecine)熔点264-7℃(分解)〔d〕p+31.3(CHcl_3:ch_3OH,8:2)〔2、3〕。提取物中尚有小量10羟基喜树碱(10-hy-
Second, quinoline alkaloids This type of alkaloids is divided into 1, cinchona alkaloids, Fujian and Taiwan provinces have no production of this alkaloid plant. 2, Camptotheca alkaloids. 3, relatively simple quinoline alkaloids and other three categories. They are described as follows: (i) Camptotheca alkaloids: These alkaloids have an anti-cancer effect. They were the roots and roots of Campto-theca acuminata Decne from the late 1950s. And leaf extract [1] [7], found to have anti-cancer effects. Later, in 1966, Wall et al. found that the extract of the bark of the tree bark had pharmacological activity against adenocarcinoma-755, and it was further confirmed that the active ingredient was Camptothecine, which had a melting point of 264-7°C (decomposition) [d]p+ 31.3 (CHcl_3: ch_3OH, 8:2) [2, 3]. A small amount of 10 hydroxycamptothecin (10-hy-