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采用链脲佐菌素 (STZ)腹腔注射建立糖尿病大鼠模型 ,观察中药复方止消通脉宁对其肾小球细胞外基质 (ECM)成分的影响。结果显示 :止消通脉宁能够明显减少糖尿病大鼠肾小球ECM主要成分ColIV、FN、LN的积聚 ,具有抑制ECM增生的作用 ,从而可以延缓糖尿病肾病发生发展的病理进程
Diabetic rat model was established by intraperitoneal injection of streptozotocin (STZ) to observe the effect of Chinese medicine compound Zhishaotongmaixin on the glomerular extracellular matrix (ECM) composition. The results showed that Zhixiao Tongmaining can significantly reduce the accumulation of glomerular ECM components ColIV, FN and LN in diabetic rats and inhibit the proliferation of ECM, which can delay the pathogenesis of diabetic nephropathy.