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目的:探讨高迁移率蛋白1(HMGB-1)和肿瘤特异性生长因子(TSGF)联合检测诊断甲状腺癌的临床价值。方法:使用ELISA试剂盒检验86例经病理证实的甲状腺癌患者,78例结节性甲状腺肿患者和69例健康人对照组的血浆HMGB-1和TSGF水平。分析血浆HMGB-1及TSGF水平与临床病理参数间的关系。结果:TSGF和HMGB-1在3组之间的差异具有统计学意义(均P<0.05),以甲状腺癌最高,结节性甲状腺肿次之,健康人最低。HMGB-1/TSGF的曲线下面积为0.912,联合检测对甲状腺癌的诊断价值大于HMGB-1和TSGF单独检测(均P<0.05)。甲状腺癌患者血浆HMGB-1及TSGF水平与患者性别、年龄、淋巴结转移及临床分期无关(均P>0.05)。结论:HMGB-1与TSGF联合检测对甲状腺癌的早期诊断有一定的应用价值。
Objective: To investigate the clinical value of combined detection of high mobility group-1 (HMGB-1) and tumor-specific growth factor (TSGF) in the diagnosis of thyroid cancer. Methods: Serum levels of HMGB-1 and TSGF in 86 patients with pathologically confirmed thyroid cancer, 78 patients with nodular goiter and 69 healthy controls were tested by ELISA kit. The relationship between plasma HMGB-1 and TSGF levels and clinicopathological parameters was analyzed. Results: The difference of TSGF and HMGB-1 between the three groups was statistically significant (all P <0.05). The highest thyroid cancer, the second was nodular goiter, and the lowest was healthy person. The area under the curve of HMGB-1 / TSGF was 0.912. The diagnostic value of combined detection of HMGB-1 / TSGF in thyroid cancer was higher than that of HMGB-1 and TSGF alone (all P <0.05). The serum levels of HMGB-1 and TSGF in thyroid cancer patients were not related to the gender, age, lymph node metastasis and clinical stage (all P> 0.05). Conclusion: Combined detection of HMGB-1 and TSGF has some value in the early diagnosis of thyroid cancer.