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作者对3801名5～11月龄的婴儿进行百日咳无细胞菌苗双盲安慰剂对照试验。随机选择954名婴儿注射安慰剂;1419名婴儿注射经福尔马林脱毒的淋巴细胞增多促进因子(LPF)和丝状血凝素(FHA)组分菌苗(JNIH-6);1428名婴儿注射LPF-类毒素菌苗(JNIH-7)。7～13周后,对3724名婴儿注射第2针。结果表明,注射后出现的副反应轻微,试验组局部反应比安慰剂组多,特别是在注射第2针JNIH-6菌苗后。局部发红(10～45mm)和肿胀(10～50mm)发生率,JNIH-6组比JNIH-7或安慰剂组都多。在注射第1针
The author of 3801 5 to 11 month-old infants with pertussis acellular double-blind placebo-controlled trials. A total of 954 infants were randomized to placebo; 1419 infants were injected with formalin-deprived LPF and FN components vaccine (JNIH-6); 1428 Infants were injected with LPF-toxoid vaccine (JNIH-7). After 7 to 13 weeks, 3724 infants were injected with the second needle. The results showed slight side effects after injection, with more local reactions in the experimental group than in the placebo group, especially after injection of the second needle JNIH-6 vaccine. Local redness (10 ~ 45mm) and swelling (10 ~ 50mm) incidence, JNIH-6 group than in JNIH-7 or placebo group. In the injection of the first needle